When your attack is auto-aimed, it prioritizes the closest target to you.
Byron is outstanding at supporting close-ranged Brawlers like Edgar as Byron's allies can play aggressively, and if applicable, ambush enemies with their Supers or by bush-camping while Byron can consistently and quickly heal them from a safe distance.
In addition, he’s also effective at preventing enemies from healing, making it easier to cripple the enemy team. Doing so will almost guarantee a positive outcome as the healing decreases enemy damage while assisting allies.
Byron's long range, high tick damage, and healing abilities truly shine in Team Events because he can consistently heal his teammates and himself with his attack, Super, and Shot In the Arm Gadget alike while they work towards the event objective with the healing giving more ease.
This strategy will allow Byron to better secure defeats.
To take advantage of Byron’s range is to chip away at enemies with his stacking tick damage while also dodging their fire, and once they’re low on health, you can use your Super to finish them off.
Unless there are no enemies near faraway allies, prioritize allies closest to you. However, with his fast projectile speed, aiming with Byron is easier than with other long-ranged Brawlers such as Brock or Bea.
Since his range is long but his cooldown is slow, sharpshooting skills, such as aiming ahead of the enemy's direction of travel, are needed to utilize Byron well.
Like Sprout‘s Overgrowth Star Power, Byron doesn’t require all three ammo to charge the bar. When the bar is charged up after 3.5 seconds, Byron’s next attack pierces through any target. Byron gains a bar similar to Bibi's Home Run bar.